Preceding influenza infection impacts neutrophil response to Aspergillus fumigatus and Staphylococcus aureus.

ABSTRACT: Influenza infection predisposes individuals to secondary pneumonia caused by a range of pathogens, including both bacterial and fungal organisms. Neutrophils are critical effector cells during infection. In this study, we analyzed the transcriptional pathways of lung neutrophils isolated from mouse models of influenza-associated pulmonary aspergillosis (IAPA) and post-influenza methicillin-resistant Staphylococcus aureus (MRSA) pneumonia to examine the immunopathological mechanisms underlying post-influenza super-infection. Pathways associated with neutrophil chemotaxis and degranulation were inhibited in IAPA compared to singular A. fumigatus infection and pathways associated with neutrophil recruitment and phagocytosis were inhibited in IAPA compared to singular influenza infection. Path

SUBMITTER: Naghshtabrizi N 

PROVIDER: S-EPMC12643476 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature