Platelets impair the resolution of inflammation in atherosclerotic plaques in insulin-resistant mice after lipid lowering.

ABSTRACT: Insulin resistance impairs benefits of lipid-lowering treatment, as evidenced by higher cardiovascular disease risk in individuals with type 2 diabetes versus those without. Because platelet activity is higher in insulin-resistant patients and promotes atherosclerosis progression, we questioned whether platelets impair inflammation resolution in plaques during lipid lowering. In mice with obesity and insulin resistance, we induced advanced plaques and then implemented lipid lowering to promote atherosclerotic plaque inflammation resolution. Concurrently, mice were treated with either platelet-depleting or control antibodies for 3 weeks. Platelet activation and insulin resistance were unaffected by lipid lowering. Both antibody-treated groups showed reduced plaque macrophages, but plaque ce

SUBMITTER: Laskou M 

PROVIDER: S-EPMC12643486 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature