C1q limits cystoid edema by maintaining basal β-catenin-dependent signaling and blood-retina barrier function.

ABSTRACT: Macular edema (ME) can cause profound vision impairment and occurs in several prevalent retinal diseases, including diabetic retinopathy, choroidal neovascularization, retinal vein occlusion, and uveitis. Retinal edema typically results from dysfunction of the blood-retina barrier (BRB), which is associated with increased retinal expression of complement components. It is unclear whether the classical complement pathway has detrimental or protective roles in the context of BRB dysfunction. Here, we characterized Tspan12-KODBM (disrupted BRB maintenance) mice, a mouse model of cystoid edema generated by genetically and pharmacologically manipulating β-catenin-dependent norrin/frizzled-4 (FZD4) signaling. We assessed BRB function, cystoid edema, electroretinogram, and microglia activation ou

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12643494 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature