Characterization of anticancer therapy-induced microvascular dysfunction in patients with breast cancer supports targeted intervention.

ABSTRACT: BACKGROUNDCardiotoxicity is a major complication of anticancer therapy (CTx); however, the effect of CTx on the microcirculation is not well defined. This study evaluated the effect of CTx on microvascular function in patients with breast cancer (PwBC).METHODSEndothelial function and angiogenic potential were assessed in arterioles and adipose biopsies obtained from PwBC undergoing CTx (longitudinal and cross-sectional) and in healthy arterioles exposed to doxorubicin (Dox), trastuzumab (TZM), or paclitaxel (PTX) ex vivo. VEGF-B protein was used to test feasibility of targeted intervention.RESULTSPwBC treated with Dox and/or TZM developed profound microvascular endothelial dysfunction that persisted for ≥ 9 months after treatment cessation. Angiogenic potential was reduced during CTx and r

SUBMITTER: Terwoord JD 

PROVIDER: S-EPMC12643535 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature