CD5 mediates the link between CD4+ CD39+ activated Treg cells and gastric cancer: A Mendelian randomization study.

ABSTRACT: Gastric cancer (GC) remains one of the leading causes of cancer mortality worldwide. The tumor immune microenvironment plays a pivotal role in GC progression, with regulatory T cells (Tregs), particularly the CD4+ CD39+ subset, implicated in immune suppression. However, the causal role of CD4+ CD39+ Treg cells in GC remains unclear. Additionally, CD5, a T cell surface glycoprotein, may influence immune responses in cancer. This study aims to clarify the relationship between CD4+ CD39+ Treg cells and GC risk and explore the potential mediating role of CD5 using a Mendelian randomization (MR) approach. A bidirectional 2-sample MR analysis was conducted using genome-wide association study data. CD4+ CD39+ Treg cell data were sourced from the IEU genome-wide association study database (N = 292

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12643594 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature