Causal associations of inflammatory proteins and plasma metabolites with Clostridium difficile colitis: A Mendelian randomization study.

ABSTRACT: This Mendelian randomization (MR) study investigates the causal relationships between circulating inflammatory proteins, blood metabolites, and Clostridium difficile colitis (CDC), with a focus on potential metabolic mediation. Bidirectional and mediation MR analyses were performed using genome-wide association study (GWAS) summary statistics from 3384 CDC cases and 406,048 controls. The primary MR methods included inverse variance weighting (IVW) and MR-Egger regression, with MR-PRESSO applied to detect and correct horizontal pleiotropy. Sensitivity analyses, including leave-one-out tests, were conducted to ensure the robustness of the findings. Mediation analysis was performed using a two-step MR framework to estimate the causal effects of inflammatory proteins on metabolites and, subseq

SUBMITTER: Dong G 

PROVIDER: S-EPMC12643595 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature