A study revealed the impact of gut microbiota on acne vulgaris: Evidence based on Mendelian randomization.

ABSTRACT: Cumulative evidence has demonstrated an association between gut microbiota and acne vulgaris. However, previous studies have yielded mixed results, and despite extensive investigations, the causal relationship between them remains unclear. The genome-wide association studies summary data of 196 gut microbiota and acne vulgaris was obtained from the most extensive available genome-wide association studies database. A 2-sample Mendelian randomization (MR) study, which utilizes genetic variants as instrumental variables in 2 independent datasets to assess causal relationships between an exposure and an outcome, was used to test the causal relationship between the gut microbiota and acne vulgaris. The MR analysis was primarily performed with the inverse variance weighted method, and MR-Egger,

SUBMITTER: Tang Y 

PROVIDER: S-EPMC12643615 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature