Waist-to-hip ratio and female infertility: An observational study and Mendelian randomization analysis.

ABSTRACT: Central adiposity, measured by waist-to-hip ratio (WHR), is a modifiable risk factor for female infertility, yet its causal role remain underexplored. Combining observational data from National Health and Nutrition Examination Survey (N = 1530 women) and Mendelian randomization (MR) using genome-wide association study summary statistics (GIANT, FinnGen, and IEU), we assessed WHR-infertility associations. Analyses included weighted logistic regression, threshold detection via generalized additive models, subgroup analyses, 2-sample MR and multivariable Mendelian randomization. Sensitivity analyses (MR-Egger, leave-one-out, MR-presso) were used to confirm robustness. Each 0.1 unit increase in WHR increased infertility risk by 46%, and WHR adj body mass index (BMI) was associated with a 23% h

SUBMITTER: Wu S 

PROVIDER: S-EPMC12643627 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature