Intertwined and unequal causality of type 1 diabetes and autoimmune thyroid disease: Insights from Mendelian randomization.

ABSTRACT: The relationship between type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) remains controversial. This study aims to analyze the potential causal relationship between T1D and AITD using bidirectional Mendelian randomization (MR). Single nucleotide polymorphisms associated with T1D, autoimmune thyroiditis (AIT), and Graves' disease (GD) were sourced from FinnGen. Inverse variance weighted, MR-Egger, and weighted median methods were employed to analyze these associations. The MR-Egger intercept was utilized to assess horizontal pleiotropy. Cochran Q and leave-one-out analyses were conducted to evaluate heterogeneity and sensitivity, respectively. The MR analysis indicated that T1D was potentially associated with an increased risk of AIT (odds ratio [OR] = 1.128, 95% confidence inte

SUBMITTER: Wu J 

PROVIDER: S-EPMC12643638 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature