Causal associations between 1400 circulating metabolites and spontaneous abortion: A bidirectional 2-sample Mendelian randomization study.

ABSTRACT: Spontaneous abortion (SA) affects approximately 10% to 15% of clinically recognized pregnancies. The potential causal role of metabolic disturbances in SA remains poorly defined. We performed a bidirectional 2-sample Mendelian randomization (MR) analysis to evaluate causal associations between 1400 plasma metabolites and SA. Genetic instruments for metabolites were obtained from a genome-wide association study of 8299 individuals from the Canadian longitudinal study on aging. Summary statistics for SA were derived from the FinnGen R12 dataset, including 23,167 cases and 1,99,279 controls. Primary MR analyses used the inverse variance weighted method, with MR-Egger, weighted median, Mendelian Randomization Pleiotropy RESidual Sum and Outlier, and leave-one-out analyses conducted to assess r

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12643647 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature