Efficacy and safety of Cyperus rotundus extract on weight management in obese individuals: A randomized, double-blind, placebo-controlled study.

ABSTRACT:

Background

Obesity, a critical public health issue, is linked to numerous metabolic and cardiovascular disorders. Natural products may present a safer and more holistic approach to weight management. A standardized extract of Cyperus rotundus (CRE), containing 6% to 8% stilbenes (scirpusin A, scirpusin B, and piceatannol) was effective in reducing adipogenesis and weight gain in preclinical studies. This study aimed to assess the efficacy and safety of CRE combined with the bioavailability enhancer piperine (CREP), as a natural supplement for managing weight in obese individuals.

Methods

A randomized, double-blind, placebo-controlled trial was conducted over 90 days involving 96 obese participants. Subjects received oral supplementation of 500 mg CRE with 5 mg piperine (CREP

SUBMITTER: Majeed A 

PROVIDER: S-EPMC12643649 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature