Impact of indocyanine green fluorescence angiography on the prevention of anastomotic leakage in mid- and low-rectal cancer surgery: A systematic review and meta-analysis.

ABSTRACT:

Background

The cause of AL in rectal cancer surgery is multifactorial. The impact of indocyanine green fluorescence angiography (ICG-FA)-based assessment of blood flow on anastomotic leakage (AL) prevention in low- and mid-rectal cancer surgery is unclear. The aim of this meta-analysis was to evaluate that impact.

Methods

The MEDLINE, Cochrane Library, and Scopus databases were searched for articles published up to September 19, 2025 in which the association between ICG-FA and outcomes of rectal cancer surgery was assessed. Data were pooled for meta-analysis. The primary outcome was the AL rate in mid- and low-rectal cancer surgery. Secondary outcomes included severity of AL, diverting-stoma construction rates, and changes in surgical plans based on ICG-FA. Subgroup analysis

SUBMITTER: Kojima T 

PROVIDER: S-EPMC12643650 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature