Exploring the molecular mechanisms of comorbidity between autism spectrum disorder and sleep disturbances through multi-dataset integration.

ABSTRACT: Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by social interaction impairments and repetitive behaviors, often accompanied by sleep disturbances (SD). Despite extensive research, the molecular mechanisms underlying the co-occurrence of ASD and SD remain unclear. This study integrated gene expression data from the GEO database for ASD and SD. We performed differential gene expression analysis, functional enrichment analysis, and weighted gene co-expression network analysis (WGCNA) to identify key genes and pathways associated with both conditions. Additionally, we explored the potential regulatory roles of microRNAs (miRNAs) and transcription factors, and evaluated the therapeutic potential of drug repositioning using the CMap database. We identifi

SUBMITTER: Li Y 

PROVIDER: S-EPMC12643707 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature