Correlation analysis of breast cancer molecular characteristics and epithelial-mesenchymal transition in circulating tumor cells: Based on clinical cases.

ABSTRACT: Breast cancer is a widely occurring malignancy, distinguished by intricate modifications in cellular signaling pathways, with epithelial-mesenchymal transition (EMT) recognized as a pivotal mechanism that propels its pathogenesis. EMT significantly facilitates the invasion and metastasis of tumor cells and profoundly affects patient prognosis. This research aims to clarify the relationship between 3 distinct types of circulating tumor cells (CTCs)-epithelial, hybrid, and mesenchymal-their EMT status, and the associated clinical and pathological features in breast cancer patients. A cohort of 48 breast cancer patients was enrolled, utilizing CanPatrol technology to isolate and classify CTCs from peripheral blood samples. Comprehensive multiplex mRNA in situ detection was employed, utilizing

SUBMITTER: Guan J 

PROVIDER: S-EPMC12643710 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature