Bioavailable testosterone and thyroid cancer: A 2-sample Mendelian randomization study.

ABSTRACT: This study explores the potential causal relationship between bioavailable testosterone (BioT) and thyroid carcinoma using 2-sample Mendelian randomization. The research data were collected from the genome-wide association studies (GWASs). Two sets of genetic variants data of BioT from the UK Biobank (male cohort contains 1,78,782 samples and female cohort contains 1,88,507 samples). Thyroid carcinoma outcomes were selected from the FinnGen GWAS (989 thyroid carcinoma cases and 2,17,803 control cases). One hundred forty-nine and 96 single nucleotide polymorphisms (SNPs) closely related to BioT were selected as IVs in female cohort and male cohort respectively. Mendelian randomization (MR) was conducted by inverse variance weighted (IVW), weighted median and MR-Egger. At the same time, MR-E

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12643742 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature