Differentially expressed genes and therapeutic targets for nonalcoholic fatty liver disease from transcriptomic techniques.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver conditions globally. Lifestyle interventions are currently available as the main treatment modality. However, there is an urgent need to develop new therapeutic approaches for NAFLD owing to its complex pathological mechanisms. This study aimed to reveal potential therapeutic targets for NAFLD through molecular mechanism analysis. Using publicly available microarray datasets, we performed differentially expressed gene analysis to identify gene expression changes in NAFLD samples relative to healthy ones. Subsequently, expression-quantitative trait loci (eQTL) and Mendelian randomization (MR) analyses were applied to evaluate the relationship between these genes and NAFLD. Additionally, the potential functional

SUBMITTER: Li J 

PROVIDER: S-EPMC12643743 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature