Causal relationship between duration of mobile phone use and risk of aneurysmal subarachnoid hemorrhage: A 2-sample Mendelian randomization analysis.

ABSTRACT: This study investigates whether the duration of mobile phone use (DMPU) is causally associated with the risk of aneurysmal subarachnoid hemorrhage (aSAH). We pooled data from publicly available genome-wide association studies. DMPU was assessed in European populations (n = 456972), and genome-wide association studies data on patients with aSAH were obtained from the Common Metabolic Disease Knowledge Portal (total n = 337159; cases = 7480; controls = 329679). Inverse-variance weighted was applied as the primary Mendelian randomization (MR) method, and 2-sample MR analyses with sensitivity tests were performed. Twenty-three single nucleotide polymorphisms reaching genome-wide significance were selected as instrumental variables for DMPU. Inverse-variance weighted analysis suggested a causal

SUBMITTER: Gao W 

PROVIDER: S-EPMC12643760 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature