Network pharmacology-based investigation of potential targets of mulberry twig acting on polycystic ovary syndrome.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a polygenic multifactorial systemic inflammatory autoimmune disease. Mulberry twig (MT) has pharmacological activities such as anti-inflammatory, hypoglycemic, anti-oxidant, and insulin resistance. Our study aimed to understand whether MT can affect PCOS and to assess its potential targets.

Methods

PCOS targets were searched using the OMIM, TTD, and GeneCards databases. The active components and corresponding protein targets of MT were searched in the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, and the compound-target network was constructed using Cytoscape 3.8.0. The intersection of the compound and disease targets was obtained, and the coincidence target was imported into the STRING database to construc

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC12643765 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature