Identification of biomarkers of Shenhailong formula in benign prostatic hyperplasia treatment: An observation study using network pharmacology and Mendelian randomization analysis.

ABSTRACT: Shenhailong formula, a classic herbal prescription, shows potential in treating benign prostatic hyperplasia (BPH), but its candidate components and mechanisms remain unclear. This study aimed to preliminarily clarify its therapeutic mechanisms in BPH using network pharmacology, Mendelian randomization (MR), and molecular docking. In this study, BPH-related datasets were first obtained from Gene Expression Omnibus database, and different expression analysis was performed to identify differentially expression genes. Meanwhile, Chinese herbs related target genes and BPH-related target genes were retrieved from public database, and candidate genes were screened by taking the intersection of the 3 above. Subsequently, MR analysis was conducted to explore the causal relationship between candida

SUBMITTER: Pan J 

PROVIDER: S-EPMC12643769 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature