Network pharmacology and molecular docking analysis of Yishenqingzhuo oral liquid for chronic kidney disease.

ABSTRACT: To examine the potential mechanisms of Yishenqingzhuo oral liquid (YSQZ) as a treatment for chronic kidney disease (CKD). The Traditional Chinese Medicine Systems Pharmacology and HERB databases were used to identify active ingredients and targets of YSQZ, and the GEO database was employed to screen CKD-related targets. Protein-protein interaction networks and enrichment analysis was conducted. Core targets and ingredients were identified from the protein-protein interaction network. Immune infiltration analysis was performed, and core targets and ingredients were validated via molecular docking. There were 97 active ingredients, 479 drug-predicted targets, 185 potential targets that were the same among the 479 drug-predicted targets and the 7193 CKD-related targets, 98 potential targets w

SUBMITTER: Zhao A 

PROVIDER: S-EPMC12643774 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature