Aversion Encoding and Behavioral State Modulation of Physiologically Defined Cell Types in the Lateral Habenula.

ABSTRACT: The lateral habenula (LHb) integrates aversive information to regulate motivated behaviors. Despite recent advances in identifying neuronal diversity at the molecular level, in vivo electrophysiological diversity of LHb neurons remains poorly understood. Understanding this diversity is essential for deciphering how information is processed in the LHb. To address this gap, we conducted in vivo juxtacellular recording and labeling of single LHb neurons in mice. Morphological analysis revealed a direct axonal projection of LHb neurons to the mediodorsal thalamus. To analyze in vivo LHb firing patterns, we applied an unsupervised clustering algorithm. This analysis identified four distinct spontaneous firing patterns of LHb neurons, which were consistent across both anesthetized and awake stat

SUBMITTER: Zouridis IS 

PROVIDER: S-EPMC12643828 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature