Toxicological assessment of <i>Chlorella vulgaris</i> and its potential preventive effect in a chronic obstructive pulmonary disease (COPD) mouse model.

ABSTRACT: Green microalgae, particularly Chlorella vulgaris, are a rich source of bioactive and nutritional compounds, making them promising candidates for nutraceutical applications. This study evaluated the antioxidant capacity, phenolic composition, and potential health effects of Chlorella vulgaris supplementation (1% and 8%) in male BALB/c mice over 4 weeks, as well as its preventive role in a murine model of chronic obstructive pulmonary disease (COPD). The extract showed a high antioxidant potential, supported by its phenolic and carotenoid profile. Supplementation, especially at 8%, enhanced antioxidant defences without signs of liver or kidney toxicity. In the COPD model, C. vulgaris reduced inflammation, improved oxidative stress balance, and partially restored normal

SUBMITTER: Giambastiani L 

PROVIDER: S-EPMC12643852 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature