Clinicopathologic characteristics and prognosis of basaloid squamous cell carcinoma of the rectum in comparison with adenocarcinoma: a retrospective cohort study.

ABSTRACT:

Objective

Basaloid squamous cell carcinoma (BSCC) is a rare histological subtype of rectal cancer. This study aimed to investigate the clinicopathologic features and survival outcomes of primary rectal BSCC and to compare them with those of adenocarcinoma (AD).

Methods

Patients diagnosed with rectal BSCC and AD patients were identified from the Surveillance, Epidemiology, and End Results database from 2000 to 2019. Univariable and multivariable Cox regression analyses were performed to identify potential risk factors for survival in BSCC patients. A nomogram was constructed to predict the prognosis of BSCC patients.

Results

A total of 257 BSCC and 77,094 AD patients were identified. BSCC patients were more significantly correlated with female gender, early clinical st

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12643862 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature