Serum osteopontin as a prognostic biomarker in acute exacerbations of chronic obstructive pulmonary disease.

ABSTRACT: Osteopontin, a phosphorylated glycoprotein, is highly expressed in lung tissues and is elevated in inflammatory diseases. However, its role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains unclear. A total of 281 AECOPD patients, 89 stable COPD (SCOPD) cases, and 89 healthy volunteers were enrolled in this prospective cohort according to the inclusion and exclusion criteria. Demographic information and clinical features were obtained from electronic medical records systems. Fasting venous blood was collected on the day of admission, and baseline serum osteopontin was measured using an enzyme-linked immunosorbent assay. The primary endpoints-death, frequency of acute exacerbations, and hospital length of stay-were evaluated through a follow-up study. Baseline

SUBMITTER: Ma KS 

PROVIDER: S-EPMC12643881 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature