Gut Microbe Fermentation of Moringa oleifera Leaf Extract Increases Measurable Polyphenols and Improves Barrier Function in a Cell Culture Model.

ABSTRACT: Moringa oleifera is associated with several nutritional and therapeutic benefits. However, there is limited research on how much these health benefits are mediated directly by the plant or through fermentation with intestinal microbes. We examined the interaction between M. oleifera aqueous leaf extract and three common gut microbes whose abundance was significantly altered in previous intervention studies. Growth curves of Escherichia coli, Bifidobacterium longum, and Bacteroides thetaiotaomicron were examined in the presence of increasing concentrations of M. oleifera leaf extract in YCFA media with and without carbohydrates and short chain fatty acids (SCFAs). Anthrone and Fast Blue BB assays were conducted on spent media to measure carbohydrate and phenolic content, respectively. Steri

SUBMITTER: Kable ME 

PROVIDER: S-EPMC12643947 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature