Tapered fiber probe-based optical cardiac pacemaker.

ABSTRACT:

Introduction

The disorders of cardiac rhythm usually induce severe cardiovascular pathologies which might pose significant threats to human health. Although multiple cardiac pacing modalities have been developed, most of them face potential limitations including structural complexity, spatiotemporal imprecision and invasive implantation requirements, thereby constraining their widespread biomedical applications.

Methods

By leveraging the unique long-range focusing capability, we establish a tapered-fiber-probe (TFP) strategy enabling non-contact and highprecision near-infrared (NIR) optical pacing in zebrafish embryos, where sustained micron-scale spatial precision (3 μm FWHM) was achieved at physiologically relevant working distances.

Results

Systematic characterizat

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12643975 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature