Photosensitizing systems based on alginate aerogels and methylene blue for controlled release of dye for antimicrobial photodynamic therapy.

ABSTRACT: Photosensitizing systems based on methylene blue (MB)-loaded calcium alginate (CaA) and alginic acid (AA) aerogels were developed for photodynamic therapy of difficult-to-heal wounds. Hybrid aerogels incorporating polyvinylpyrrolidone (PVP, 2.5-40 wt%) into CaA and AA matrices were also made. The MB release kinetics in a phosphate buffer were found to depend on the aerogel type (AA or CaA). The incorporation of PVP increased the MB release rate by 1.5-2 times. The singlet oxygen (¹O₂) generation efficiency of MB embedded in the aerogels was influenced by their porosity and chemical composition. The activity of MB in the photogeneration of ¹O₂ increased by up to four times in the PVP-containing aerogels. Furthermore, the photoactivity of MB in the

SUBMITTER: Shershnev I 

PROVIDER: S-EPMC12643984 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature