Safety of peripheral intravenous administration of hypertonic saline: a systematic review and meta-analysis.

ABSTRACT:

Background

Hypertonic saline solution is critical for managing symptomatic hyponatremia and increased intracranial pressure (IICP). Though administered via central venous catheters (CVCs) traditionally, peripheral administration is a viable alternative, reducing delays and CVC-associated risks. This review evaluates the safety of peripheral hypertonic saline, focusing on infusion-related adverse events.

Methods

A systematic search of MEDLINE, Embase, and Cochrane Library (up to December 2024) identified studies on peripheral hypertonic saline in adults. Studies reporting phlebitis, infiltration, extravasation, and thrombosis were included. Two reviewers independently screened studies and extracted data. Quality was assessed using the Newcastle-Ottawa Scale and Risk of Bias 2

SUBMITTER: Huang SS 

PROVIDER: S-EPMC12644001 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature