Immunization with outer membrane vesicles drived <i>Proteus mirabilis p</i>rotects mice against bacteria-induced lethality.

ABSTRACT:

Introduction

Proteus mirabilis (Pm) has emerged as a significant and widespread opportunistic pathogen affecting both humans and animals, resulting in substantial economic losses within the agricultural sector. While most conventional antibiotics remain effective against Pm infections, the rise of multidrug-resistant strains has considerably complicated disease management. Outer membrane vesicles (OMVs), which are vesicular structures secreted by Gram-negative bacteria, have been identified in numerous studies as potential antigenic components or immune adjuvants for the development of novel vaccines.

Methods

In this study, Proteus mirabilis outer membrane vesicles (Pm_OMVs) were employed to immunize mice, followed by the execution of Pm in

SUBMITTER: Fan W 

PROVIDER: S-EPMC12644052 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature