Differences in firing patterns along the dorsal-intermediate hippocampal axis in a fixed route during a change in emotional context.

ABSTRACT: The hippocampus plays a prominent role in spatial navigation and memory. However, differences exist along the hippocampus longitudinal axis in function and connectivity. The current study focuses on the dorsal and intermediate subregions of the hippocampus. Single unit CA1 activity was recorded in a fixed route task with a change in emotional valence. We hypothesized the intermediate subregion to show greater changes in general firing activity and place cell remapping in response to emotional change in context compared to the dorsal subregion. Animals were trained to run back and forth for food on a U-shaped maze. In half the trials, animals were presented with a tone which signaled an active shock zone at the apex of the maze. Therefore, animals alternated between "safe" and "unsafe" emot

SUBMITTER: Troha R 

PROVIDER: S-EPMC12644059 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature