Albumin coatings for counteracting uremic metabolites effects on host responses to biomaterials.

ABSTRACT: Chronic kidney disease is a progressive condition characterized by a decline in kidney function that is the impetus for an increased retention of uremic metabolites (UMs) in the blood compartment which is correlated with adverse patient outcomes. The inefficient clearance of some UMs using membrane hemodialysis is a significant problem, and adsorptive materials are actively being researched to overcome this issue. Albumin is an abundant serum protein known to bind UMs and minimize non-specific protein adsorption at albumin-modified surfaces: two important aspects for designing modified surfaces for clearing UMs from blood. Herein, we anchored albumin to nanoparticles to understand if UM effects on protein-driven host responses to nanoparticles could be minimized. UM doped platelet-poor pla

SUBMITTER: Sharma I 

PROVIDER: S-EPMC12644085 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature