Stage IA and IC adult granulosa cell tumors: Clinical features, long-term outcomes and prognostic factors in a 333-patient cohort over three decades.

ABSTRACT:

Background

Adult granulosa cell tumors (AGCTs) are rare low-grade malignant ovarian tumors, with 80-90% diagnosed at FIGO stage I. This study aimed to identify prognostic factors and refine management for stage I AGCT.

Methods

In this 30-year retrospective cohort study, patients with stage I AGCT between January 1988 and January 2024 were selected and reviewed in total cohort and subgroups according to tumor stage.

Results

This retrospective study analyzed 333 eligible AGCT cases, including 196 patients (58.9%) with FIGO stage IA and 137 (41.1%) with stage IC. After a median follow-up of 138.5 ± 108.0 months, recurrence occurred in 55 patients (40.1%) in the IC group, significantly higher than that in the IA group (38 patients, 19.4%; P < 0.001, FDR = 0.005). Approxim

SUBMITTER: Gan J 

PROVIDER: S-EPMC12644150 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature