Lineage plasticity and signal dysregulation define the cellular trajectory of osteoarthritis progression.

ABSTRACT: This study aims to explore the plastic changes in cell lineages during the progression of osteoarthritis (OA) and their relationship with dysregulation of signaling pathways and provide new molecular targets for precise treatment. Single-cell RNA sequencing (scRNA-seq) technology was utilized to perform high-resolution cell lineage analysis of OA patients. The mappings of distinct cell subpopulations were systematically constructed and revealed the changes in key cell types and their transformation trajectories throughout the progression of OA. Furthermore, KEGG and GO enrichment and pseudotime trajectory analysis were applied to elucidate the functional reprogramming of different cell types and the dynamic imbalance of their signaling networks in OA. Additionally, in vitro experiments wer

SUBMITTER: Chen G 

PROVIDER: S-EPMC12644171 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature