Study on the regulation of Treg cell infiltration by EZH2 through CXCR4/CXCL12 in diffuse large B-cell lymphoma.

ABSTRACT: Enhancer of Zeste Homolog 2 (EZH2) is an important methyltransferase, which is overexpressed in a variety of tumors and is involved in promoting tumor growth and immune escape. Both EZH2 and C-X-C chemokine receptor type 4 (CXCR4) exhibit high-level expression in the germinal centers of lymph nodes. However, it remains unclear whether there exists a synergistic relationship between these two molecules. Our study found that approximately 90.7% of cases of diffuse large B-cell lymphoma (DLBCL) exhibited medium-to-high intensity expression of both EZH2 and CXCR4. CXCR4 and C-X-C motif chemokine ligand 12 (CXCL12) are a pair of receptor-ligands, which are related to tumor invasion and migration and immune cell infiltration in the tumor background. Our study found that the expression intensity

SUBMITTER: Wang H 

PROVIDER: S-EPMC12644176 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature