Genetic and epidemiologic assessment of mandibular cortical indices and bone mineral density in peripubertal children: the Generation R study.

ABSTRACT:

Objectives

The panoramic mandibular index (PMI) and mental index (MI) assessed on dental panoramic radiographs (DPRs) have been postulated as useful for the assessment of adult bone health. However, their utility in children remains to be determined. Our objective was to establish genetic determinants of the PMI/MI and to evaluate the relationship between these indices and total body less-head bone mineral density (TBLH-BMD).

Methods

This study was embedded in the Generation R Study at a mean age of 13 years. BMD was obtained from dual-energy X-ray (DXA) scans, while radiomorphometric measurements of the mandibular bone were obtained from DPRs. Genome-wide association studies (GWAS) on PMI/MI were performed. The association between PMI/MI and BMD was assessed following a com

SUBMITTER: Prijatelj V 

PROVIDER: S-EPMC12644194 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature