Development and validation of mitochondrial metabolism-related genes in the prognostic and immunological characterization of clear cell renal cell carcinoma.

ABSTRACT: As the most prevalent subtype of renal cell carcinoma, clear cell renal cell carcinoma (ccRCC) exhibits a tendency for metastasis and recurrence and demonstrates resistance to both radiotherapy and chemotherapy. Mitochondrial metabolism, as an important bioenergy hub, profoundly affects the tumor microenvironment. This study aims to screen potential biomarkers of ccRCC based on mitochondrial metabolism-related genes (MMRGs). Transcriptomic data for ccRCC patients were retrieved from the TCGA and ArrayExpress databases. An integrated analytical approach incorporating differential expression analysis, least absolute shrinkage and selection operator (LASSO) regression analysis, and multivariate Cox analysis was employed to identify prognostic genes associated with ccRCC. To elucidate the biol

SUBMITTER: Lu L 

PROVIDER: S-EPMC12644204 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature