Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles.

ABSTRACT:

Introduction

Myostatin (MSTN), a transforming growth factor-beta (TGF-β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes augmentation in skeletal muscle mass in all animal species examined. Recent studies have demonstrated that circadian clock proteins play a critical role in the regulation of muscle mass and function, in part by modulating the expression of key muscle-related genes. While myostatin has an important role in sustaining skeletal muscle protein turnover, it is unknown if circadian clock proteins regulate myostatin in a circadian pattern.

Methods

We analysed time-course muscle samples from 16 animal species ranging from Caenorhabditis elegans to humans and examined the rhythmic express

SUBMITTER: Liu X 

PROVIDER: S-EPMC12644245 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature