SLIT2 inhibits lung adenocarcinoma progression by suppressing epithelial-mesenchymal transition.

ABSTRACT: Lung adenocarcinoma (LUAD), the most common subtype of lung cancer, is a major contributor to worldwide cancer deaths. Although the slit guidance ligand (SLIT) protein family is implicated in both normal biological processes and disease states, the specific role of SLIT2 in LUAD development remains unclear. To address this gap, the present study integrated bioinformatics analyses and experimental studies to investigate the functional significance and clinical relevance of SLIT2 in LUAD. The present analysis revealed that SLIT2 expression is significantly reduced in LUAD tissues and cell lines, and this decrease is associated with poorer patient outcomes. Functional experiments showed that inhibiting SLIT2 expression enhances LUAD cell growth, migration, invasion and epithelial-mesenchymal

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12644277 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature