A predictive model for early intubation in patients with COVID-19-induced acute hypoxemic respiratory failure under awake prone position.

ABSTRACT:

Background

Awake prone positioning (APP) reduces the risk of endotracheal intubation and mortality in COVID-19-related acute respiratory failure (ARF) receiving high-flow nasal oxygen (HFNO). However, a significant proportion of patients undergoing APP are ultimately intubated, and mortality in this subgroup remains high. We aimed to develop a predictive model to be applied within the first 24 h of APP to identify patients at higher risk of progressing to intubation within 72 h of APP initiation.

Methods

We conducted a secondary analysis of a prospective multicenter cohort including adult patients with COVID-19-related ARF admitted to six intensive care units in Argentina between June 2020 and January 2021. Eligible patients received HFNO and APP for at least 6 h per day. Ph

SUBMITTER: Morales-Quinteros L 

PROVIDER: S-EPMC12644287 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature