PDK4 as a tumor suppressor in gastric cancer: implications for metabolic regulation, immune modulation, and prognostic potential.

ABSTRACT:

Objective

Gastric cancer (GC) remains a leading cause of cancer-related mortality, with growing evidence implicating metabolic regulators in its progression. This study investigates the expression pattern, prognostic significance, molecular interactions, and immunomodulatory role of pyruvate dehydrogenase kinase 4 (PDK4) in GC.

Methods

Integrated bioinformatics analyses were conducted using RNA sequencing and clinical data from the TCGA-STAD and GSE54129 datasets. Differential gene expression analysis identified co-differentially expressed genes (co-DEGs). Functional enrichment analysis, protein-protein interaction (PPI) network construction, competing endogenous RNA (ceRNA) network prediction, and immune infiltration analysis were performed. The clinical relevance of PDK4 w

SUBMITTER: Xu J 

PROVIDER: S-EPMC12644330 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature