Treatment Outcome and Associated Factors Among Women With Gestational Trophoblastic Neoplasia in Northwest Ethiopia: A Multi-Center Retrospective Cohort Study.

ABSTRACT: IntroductionGestational trophoblastic neoplasia (GTN) is the most curable gynecologic malignancy. However, resistance to first-line chemotherapy remains common, and mortality is high in developing countries.ObjectiveTo evaluate remission, relapse, survival, and associated factors among GTN patients in northwest Ethiopia.MethodsA hospital-based, multi-center retrospective cohort study was conducted on 205 patients treated between August 1, 2019, and July 31, 2024. Data were collected from medical charts and phone interviews. Logistic regression identified factors affecting remission. Kaplan-Meier analysis was used to estimate the overall survival (OS) probabilities. Prognostic factors were determined using Cox regression. Results were interpreted as adjusted odds (AOR) and adjusted hazard r

SUBMITTER: Kassaw AT 

PROVIDER: S-EPMC12644429 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature