Butyrophilin 3A/2A1-independent activation of human Vγ9Vδ2 γδ T cells by bacteria.

ABSTRACT: The activation of human Vδ2 γδ T cells by phosphoantigens (pAg) strictly depends on transmembrane butyrophilin (BTN) molecules, specifically BTN3A isoforms and BTN2A1. Several bacteria, including M. tuberculosis, produce potent pAg and thus trigger a strong activation of Vδ2 T cells. The antigen-specific activation of CD4 and regulatory (Treg) T cells can be monitored by the rapid upregulation of CD154 and CD137, respectively. We have previously established that CD137 is also rapidly upregulated on Vδ2 T cells upon stimulation with pAg. In the present study, we have used antagonistic anti-BTN3A/2A1 antibodies to dissect the pAg-dependent and pAg-independent activation of Vδ2 T cells by various microbes. While the activation of Vδ2 T cells by pAg and aminobisphosphonate zoledronate w

SUBMITTER: Gombert D 

PROVIDER: S-EPMC12644456 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature