Inhibition of microRNA-155 regulates gastric mucosal barrier repair and inflammation by targeting SOCS1 for the treatment of acute gastritis.

ABSTRACT: Acute gastritis is a common gastrointestinal disorder characterized by rapid onset of mucosal injury and infiltration of inflammatory cells, often induced by chemical irritants such as ethanol. Although inflammation is essential for mucosal defense and repair, excessive immune responses can lead to tissue damage and impaired healing. MicroRNAs (miRNAs), particularly those involved in immune regulation, have emerged as important modulators in various inflammatory conditions. However, their specific roles in the early phase of acute gastric inflammation remain unclear, and the mechanisms by which they influence mucosal damage are still not fully understood. In this study, we investigated the expression and functional significance of microRNA-155 (miR-155) in a mouse model of ethanol-induced

SUBMITTER: Luo L 

PROVIDER: S-EPMC12644493 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature