GlycoGenius: a streamlined high-throughput glycan composition identification tool.

ABSTRACT: Mass spectrometry is recognized as the gold standard for glycan analysis, yet the complexity of the generated data hampers progress in glycobiology, as existing tools lack full automation, requiring extensive manual effort. We introduce GlycoGenius, an open-source program offering an automated workflow for glycomics data analysis, featuring an intuitive graphical interface. With algorithms tailored to reduce manual workload, it allows for data visualization and automatically constructs search spaces, identifies, scores, and quantifies glycans, filters results, and annotates fragment spectra of N- and O-glycans, glycosaminoglycans and more. It seamlessly guides researchers of all expertise levels from raw data to publication-ready figures. Our findings demonstrate that GlycoGenius achieves

SUBMITTER: Loponte HF 

PROVIDER: S-EPMC12644503 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature