Identification of potential biomarkers associated with cellular senescence in benign prostatic hyperplasia.

ABSTRACT: Benign prostatic hyperplasia (BPH) is a prevalent condition among aging men, characterized by prostate enlargement and urinary symptoms. Despite its common occurrence, the molecular mechanisms, particularly those related to cellular senescence, are not well understood. This study aims to pinpoint and analyze cellular senescence-related differentially expressed genes (CSRDEGs) in BPH. We integrated data from GEO datasets GSE119195 and GSE7307, addressing batch effects to ensure data reliability. Differential gene expression analysis revealed key CSRDEGs, which were further analyzed through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, highlighting their involvement in significant biological processes and pathways such as inflammation, cell cycle regulation,

SUBMITTER: Zhou L 

PROVIDER: S-EPMC12644519 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature