Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities.

ABSTRACT: Limited knowledge currently exists regarding the shared genetic architecture influencing human cognitive ability-related traits. We utilized Genomic Structural Equation Modeling (Genomic-SEM) along with multiple post-GWAS methods to estimate potentially causal single nucleotide polymorphisms (SNPs) associated with cognitive ability phenotypic variation. Our study identified 3,842 genome-wide significant loci, including 275 novel loci. Applying multiple transcriptome-wide association methods, we analyzed susceptibility gene signal loci highly correlated with cognitive ability GWAS from tissue, cellular, and genomic element perspectives, identifying 13 high-confidence candidate causal genes and related functional element information. Subsequently, we systematically evaluated 80-90% of curren

SUBMITTER: Chen H 

PROVIDER: S-EPMC12644536 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature