DNA methyltransferase 1 correlates with immune modulation in pancreatic neuroendocrine tumors.

ABSTRACT: Epigenetic regulation is a key driver of pancreatic neuroendocrine tumors (PNETs), yet the interplay between epigenetics and immune infiltration in the PNET tumor microenvironment remains poorly understood. This study investigates associations between epigenetic regulators and immune markers in PNETs to evaluate the potential for a combination of epigenetic-targeted therapy and immunotherapy. Immunohistochemical staining was performed on specimens from twenty-five Grade 1 or Grade 2 PNET patients, along with matched adjacent benign controls from each individual. Quantification was conducted using ImageJ software, followed by statistical analysis to assess correlations between epigenetic regulation and immune modulation. DNA methyltransferase 1 (DNMT1) was significantly upregulated in PNET

SUBMITTER: Saleh Z 

PROVIDER: S-EPMC12644564 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature