Metabolomic biomarkers of psychotic conversion in ultra-high-risk subjects: a pilot study.

ABSTRACT: Psychosis is a psychiatric condition that can become a chronic and severe psychiatric disorder affecting more than 1% of the population. The ultra-high risk (UHR) patients have a transition rate to psychosis of 25% after three years. We aimed to identify circulating metabolomic biomarkers for psychotic conversion in UHR patients using nuclear magnetic resonance (NMR) spectroscopy. We used samples from 35 UHR patients: 14 converters (UHR-C) and 21 non-converters (UHR-NC) at inclusion from the ICAAR cohort. Serum samples were analysed using the high-throughput screening IVDr NMR method. R and SIMCA were used for statistical analysis. Several lipoprotein parameters related to HDL and LDL metabolism were downregulated in UHR-C compared to UHR-NC at the time of inclusion. The 3 best lipoprotein

SUBMITTER: Avella MT 

PROVIDER: S-EPMC12644573 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature