Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study.

ABSTRACT: Maternal diet and metabolic conditions, such as obesity and diabetes, are associated with consequences for offspring brain health, including effects on behaviour and an increased risk for neurodevelopmental disorders (NDDs). The extent and sequence of neuroanatomical changes to offspring brain development produced by dietary conditions have not yet been reported. In this study, we used a mouse model of parental high-fat or high-fat/high-sugar diet consumption to examine its effects on offspring brain development using longitudinal magnetic resonance imaging. We demonstrated that exposure to these parental diets through gestation and lactation resulted in offspring brain structure changes. Different temporal patterns of change were observed: some structures exhibited volume differences alre

SUBMITTER: Lee G 

PROVIDER: S-EPMC12644629 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature