Development and validation of a nomogram for predicting ectopic pregnancy in patients receiving double fresh cleavage stage embryo transfer.

ABSTRACT: Ectopic pregnancy (EP) is a common yet fatal complication of in vitro fertilization-embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI). We aim to establish and validate a nomogram in patients undergoing double fresh cleavage-stage embryo transfer, which remains a mainstream strategy in infertile patients. Data from 7456 patients were reviewed and divided into training and validation sets. Logistic analyses were conducted to identify the risk factors, with calibration and decision-curve analyses performed to evaluate model performance. The model divided patients into high- and low-risk groups, showing different 48-h serum beta-human chorionic gonadotropin (HCG) rising thresholds. It showed that Tubal factor infertility (Odds Ratio [OR] = 1.680, 95% Confidence Interval [CI]

SUBMITTER: Ge Y 

PROVIDER: S-EPMC12644677 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature